Polarization mode dispersion in radio-frequency interferometric embedded fiber-optic sensors

The effect of fiber birefringence on the propagation delay in an embedded fiber-optic strain sensor is studied. The polarization characteristics of the sensor are described in terms of polarization mode dispersion through the principal states of polarization and their differential group delay. Using these descriptors, an analytical expression for the response of the sensor for an arbitrary input state of polarization is given and experimentally verified. It is found that the differential group delay, as well as the input and output principal states of polarization, vary when the embedded fiber is strained, leading to fluctuations in the sensor output. The use of high birefringence fibers and different embedding geometries is examined as a means for reducing the polarization dependency of the sensor

Female Scent Signals Enhances Male Resistance to Influenza

Scent of receptive females as signal to reproduction stimulate male mice to olfactory search of a potential breeding partner^1, 2^. This searching behavior is coupled with infection risk due to bacterial contamination of the fecal and urine scent marks^4^. The theoretical consideration of host evolution under inevitable parasitic pressures, including helminthes, bacteria, virus etc., predicts adaptations that help protect against parasites associated with breeding^7^. In this study, we propose that acceptation of female signals by male mice leads to adaptive redistribution of immune defense directed to protection against respiratory infection risks. Our results reveal migration of macrophages and neutrophils to upper airways upon exposure to female odor stimulus resulting in increased resistance to influenza virus in male mice. Contrary to widely accepted immunosuppressive function of female sexual signals, our data provide the first demonstration of the adaptive immunological response to female odor stimulus through induction of nonspecific immune response in upper airways

Spatio-temporal development of streamflow droughts in north-west Europe

International audienceThis paper examines the spatial and temporal development of streamflow droughts in Europe over the last 40 years, differentiating the climatic factors that drive drought formation from catchment controls on drought manifestation. A novel approach for quantifying and comparing streamflow and precipitation depletion is presented. This approach considers atypical flow or rainfall events, as well as more severe droughts, regardless of the season in which they occur (although unlikely to constitute drought in an operational sense, sustained atypical flows are important with regard to understanding how droughts arise and develop). The amount of flow depletion is quantified at daily resolution based on the standardised departure from the mean day d flow, or flow anomaly. The index was derived for 2780 gauging points within north-west Europe using data from the FRIEND European Water Archive for the 1960-1995 period. Using a simple interpolation procedure these data were used to produce a time-series of grids, with a cell size of 18 km2, showing the spatial distribution of flow anomaly over the study area. A similar approach was used to characterise monthly precipitation anomalies, based on existing grid data (see New et al., 2000). The grids were analysed chronologically to examine the spatial and temporal coherency of areas showing large flow and/or precipitation anomalies, focussing on drought development during the 1975-1976 and 1989-1990 periods. Using a threshold approach, in which an anomaly of 2 standard deviations represents the onset of drought conditions, indices were developed to describe the time-varying extent and areal-severity (flow deficit) of streamflow and precipitation drought. Similar indices were used to describe how the magnitude and temporal variation of flow depletion varied spatially. In terms of streamflow depletion, the 1976 drought was found to be a highly coherent event, having a well defined start (in January 1976) and end (in September 1976). The worst and most persistent streamflow droughts occurred in southern England and northern France. Central parts of Europe experienced only severe streamflow depletion during the ?height' of the drought in June, July and August when there was negligible precipitation across large areas of Europe. In contrast, the 1989/90 period was characterised by a series of shorter and less severe droughts, with much greater variability over time. The relationship between precipitation drought and streamflow drought was less clear, which might have resulted from periods of precipitation depletion occurring randomly in time. Particularly high levels of streamflow drought were again observed in southern England and northern France. Several possible explanations for the increased drought occurrence over southern England and northern France were investigated using data from the 1976 event. However, immediately antecedent precipitation deficits could not explain the level of streamflow depletion which appears to have been enhanced by decreased discharge of groundwater into the river networks in this region. This can probably be attributed to large precipitation deficits during autumn 1975 and spring 1976: the consequent reduction in groundwater recharge ultimately led to depressed groundwater levels. Keywords: drought, streamflow depletion, streamflow drought, low-flow regimes, Drought Index</p

PMP22 exon 4 deletion causes ER retention of PMP22 and a gain-of-function allele in CMT1E

OBJECTIVE: To determine whether predicted fork stalling and template switching (FoSTeS) during mitosis deletes exon 4 in peripheral myelin protein 22 KD (PMP22) and causes gain‐of‐function mutation associated with peripheral neuropathy in a family with Charcot–Marie–Tooth disease type 1E. METHODS: Two siblings previously reported to have genomic rearrangements predicted to involve exon 4 of PMP22 were evaluated clinically and by electrophysiology. Skin biopsies from the proband were studied by RT‐PCR to determine the effects of the exon 4 rearrangements on exon 4 mRNA expression in myelinating Schwann cells. Transient transfection studies with wild‐type and mutant PMP22 were performed in Cos7 and RT4 cells to determine the fate of the resultant mutant protein. RESULTS: Both affected siblings had a sensorimotor dysmyelinating neuropathy with severely slow nerve conduction velocities (<10 m/sec). RT‐PCR studies of Schwann cell RNA from one of the siblings demonstrated a complete in‐frame deletion of PMP22 exon 4 (PMP22Δ4). Transfection studies demonstrated that PMP22Δ4 protein is retained within the endoplasmic reticulum and not transported to the plasma membrane. CONCLUSIONS: Our results confirm that that FoSTeS‐mediated genomic rearrangement produced a deletion of exon 4 of PMP22, resulting in expression of both PMP22 mRNA and protein lacking this sequence. In addition, we provide experimental evidence for endoplasmic reticulum retention of the mutant protein suggesting a gain‐of‐function mutational mechanism consistent with the observed CMT1E in this family. PMP22Δ4 is another example of a mutated myelin protein that is misfolded and contributes to the pathogenesis of the neuropathy

The last line effect explained

Micro-clones are tiny duplicated pieces of code; they typically comprise only few statements or lines. In this paper, we study the “Last Line Effect,” the phenomenon that the last line or statement in a micro-clone is much more likely to contain an error than the previous lines or statements. We do this by analyzing 219 open source projects and reporting on 263 faulty micro-clones and interviewing six authors of real-world faulty micro-clones. In an interdisciplinary collaboration, we examine the underlying psychological mechanisms for the presence of these relatively trivial errors. Based on the interviews and further technical analyses, we suggest that so-called “action slips” play a pivotal role for the existence of the last line effect: Developers’ attention shifts away at the end of a micro-clone creation task due to noise and the routine nature of the task. Moreover, all micro-clones whose origin we could determine were introduced in unusually large commits. Practitioners benefit from this knowledge twofold: 1) They can spot situations in which they are likely to introduce a faulty micro-clone and 2) they can use PVS-Studio, our automated micro-clone detector, to help find erroneous micro-clones

Weighted Dirac combs with pure point diffraction

A class of translation bounded complex measures, which have the form of weighted Dirac combs, on locally compact Abelian groups is investigated. Given such a Dirac comb, we are interested in its diffraction spectrum which emerges as the Fourier transform of the autocorrelation measure. We present a sufficient set of conditions to ensure that the diffraction measure is a pure point measure. Simultaneously, we establish a natural link to the theory of the cut and project formalism and to the theory of almost periodic measures. Our conditions are general enough to cover the known theory of model sets, but also to include examples such as the visible lattice points.Comment: 44 pages; several corrections and improvement

Pure point diffraction and cut and project schemes for measures: The smooth case

We present cut and project formalism based on measures and continuous weight functions of sufficiently fast decay. The emerging measures are strongly almost periodic. The corresponding dynamical systems are compact groups and homomorphic images of the underlying torus. In particular, they are strictly ergodic with pure point spectrum and continuous eigenfunctions. Their diffraction can be calculated explicitly. Our results cover and extend corresponding earlier results on dense Dirac combs and continuous weight functions with compact support. They also mark a clear difference in terms of factor maps between the case of continuous and non-continuous weight functions.Comment: 30 page

A new perturbative expansion of the time evolution operator associated with a quantum system

A novel expansion of the evolution operator associated with a -- in general, time-dependent -- perturbed quantum Hamiltonian is presented. It is shown that it has a wide range of possible realizations that can be fitted according to computational convenience or to satisfy specific requirements. As a remarkable example, the quantum Hamiltonian describing a laser-driven trapped ion is studied in detail.Comment: 32 pages; modified version with examples of my previous paper quant-ph/0404056; to appear on the J. of Optics B: Quantum and Semiclassical Optics, Special Issue on 'Optics and Squeeze Transformations after Einstein

Efficacy and Safety of Viltolarsen in Boys With Duchenne Muscular Dystrophy: Results From the Phase 2, Open-Label, 4-Year Extension Study

Background: Duchenne muscular dystrophy (DMD) is caused by DMD gene mutations, resulting in absence of functional dystrophin protein. Viltolarsen, an exon 53 skipping therapy, significantly increased dystrophin levels in patients with DMD. Presented here are completed study results of \u3e 4 years of functional outcomes in viltolarsen-treated patients compared to a historical control group (Cooperative International Neuromuscular Research Group Duchenne Natural History Study [CINRG DNHS]). Objective: To evaluate the efficacy and safety of viltolarsen for an additional 192 weeks in boys with DMD. Methods: This phase 2, open-label, 192-week long-term extension (LTE) study (NCT03167255) evaluated the efficacy and safety of viltolarsen in participants aged 4 to \u3c 10 years at baseline with DMD amenable to exon 53 skipping. All 16 participants from the initial 24-week study enrolled into this LTE. Timed function tests were compared to the CINRG DNHS group. All participants received glucocorticoid treatment. The primary efficacy outcome was time to stand from supine (TTSTAND). Secondary efficacy outcomes included additional timed function tests. Safety was continuously assessed. Results: For the primary efficacy outcome (TTSTAND), viltolarsen-treated patients showed stabilization of motor function over the first two years and significant slowing of disease progression over the following two years compared with the CINRG DNHS control group which declined. Viltolarsen was well tolerated, with most reported treatment-emergent adverse events being mild or moderate. No participants discontinued drug during the study. Conclusions: Based on the results of this 4-year LTE, viltolarsen can be an important treatment strategy for DMD patients amenable to exon 53 skipping